Inhibition of ifosfamide-induced urotoxicity by disulfiram in mice.
نویسندگان
چکیده
The effect of disulfiram on the urotoxicity induced by ifosfamide was studied in mice. Ifosfamide administered intraperitoneally to mice caused a dose-related increase in bladder weight within 48 hr of treatment. Disulfiram prevented ifosfamide-induced bladder damage when administered orally within 1 hr of ifosfamide treatment. The results indicate that disulfiram is an effective protective agent against bladder damage caused by ifosfamide treatment.
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 49 1 شماره
صفحات -
تاریخ انتشار 1989